| Rush Attempts | Rush Yards | Rush Touchdowns | Yards Per Rush | Pass Attempts | Completions | Pass Yards | Pass Touchdowns | Net Yards Per Passing Attempt | Rush Percentage | Pass Percentage |
|---|---|---|---|---|---|---|---|---|---|---|
| 504 | 2360 | 20 | 4.7 | 512 | 338 | 3856 | 30 | 7.1 | 0.496 | 0.504 |
| Player | Position | Games Played | Games Started | Pass Yards | Pass TDs | Completions | Attempts |
|---|---|---|---|---|---|---|---|
| Jimmy Garoppolo | QB | 11 | 10 | 2437 | 16 | 207 | 308 |
| Brock Purdy | QB | 9 | 5 | 1374 | 13 | 114 | 170 |
| Trey Lance | QB | 2 | 2 | 194 | 0 | 15 | 31 |
| Josh Johnson | QB | 2 | 0 | 10 | 0 | 1 | 2 |
| Christian McCaffrey | RB | 11 | 10 | 34 | 1 | 1 | 1 |
| Player | Position | Games Played | Games Started | Rush Attempts | Rush Yds | Rush Tds | Targets | Receptions | Receiving Yds | Receiving Tds | Fumbles | All Purpose Yds | All TD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Christian McCaffrey | RB | 11 | 10 | 159 | 746 | 6 | 65 | 52 | 464 | 4 | 1 | 1210 | 10 |
| Jeff Wilson | RB | 8 | 6 | 92 | 468 | 2 | 13 | 10 | 91 | 0 | 2 | 559 | 2 |
| Elijah Mitchell | RB | 5 | 1 | 45 | 279 | 2 | 4 | 3 | 7 | 0 | 0 | 286 | 2 |
| Jordan Mason | RB | 16 | 0 | 43 | 258 | 1 | 0 | 0 | 0 | 0 | 0 | 258 | 1 |
| Deebo Samuel | WR | 13 | 12 | 42 | 232 | 3 | 94 | 56 | 632 | 2 | 3 | 864 | 5 |
| Tyrion Davis-Price | RB | 6 | 0 | 34 | 99 | 0 | 2 | 0 | 0 | 0 | 0 | 99 | 0 |
| Jimmy Garoppolo | QB | 11 | 10 | 23 | 33 | 2 | 0 | 0 | 0 | 0 | 3 | 33 | 2 |
| Brock Purdy | QB | 9 | 5 | 22 | 13 | 1 | 0 | 0 | 0 | 0 | 0 | 13 | 1 |
| Trey Lance | QB | 2 | 2 | 16 | 67 | 0 | 0 | 0 | 0 | 0 | 1 | 67 | 0 |
| Tevin Coleman | RB | 5 | 0 | 12 | 26 | 1 | 3 | 3 | 44 | 1 | 0 | 70 | 2 |
| Kyle Juszczyk | FB | 16 | 12 | 7 | 26 | 1 | 23 | 19 | 200 | 1 | 0 | 226 | 2 |
| Ray-Ray McCloud | WR | 17 | 2 | 4 | 78 | 1 | 25 | 14 | 243 | 1 | 2 | 321 | 2 |
| Brandon Aiyuk | WR | 17 | 17 | 2 | 23 | 0 | 114 | 78 | 1015 | 8 | 1 | 1038 | 8 |
| Josh Johnson | QB | 2 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 |
| Danny Gray | WR | 13 | 0 | 1 | 9 | 0 | 7 | 1 | 10 | 0 | 0 | 19 | 0 |
| George Kittle | TE | 15 | 15 | 0 | 0 | 0 | 86 | 60 | 765 | 11 | 1 | 765 | 11 |
| Jauan Jennings | WR | 16 | 4 | 0 | 0 | 0 | 56 | 35 | 416 | 1 | 1 | 416 | 1 |
| Tyler Kroft | TE | 11 | 4 | 0 | 0 | 0 | 5 | 4 | 57 | 0 | 0 | 57 | 0 |
| Ross Dwelley | TE | 12 | 0 | 0 | 0 | 0 | 5 | 3 | 105 | 1 | 0 | 105 | 1 |
| Charlie Woerner | TE | 17 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Starter | Backup | 3rd String | 4th String | 5th String | 6th String | 7th String |
|---|---|---|---|---|---|---|
| Brock Purdy 1 - QB | Trey Lance 2 - QB | Sam Darnold 3 - QB | Brandon Allen 4 - QB | |||
| Christian McCaffrey 1 - RB | Elijah Mitchell 2 - RB | Jordan Mason 3 - RB | Tyrion Davis-Price 4 - RB | Jeremy McNichols 5 - RB | Khalan Laborn 6 - RB | |
| Deebo Samuel 1 - WR | Ray-Ray McCloud 2 - WR | Ronnie Bell 3 - WR | Dazz Newsome 4 - WR | |||
| Brandon Aiyuk 1 - WR | Danny Gray 2 - WR | Willie Snead 3 - WR | Isaiah Winstead 4 - WR | |||
| Jauan Jennings 1 - WR | Chris Conley 2 - WR | Tay Martin 3 - WR | ||||
| George Kittle 1 - TE | Cameron Latu 2 - TE | Charlie Woerner 3 - TE | Ross Dwelley 4 - TE | Brayden Willis 5 - TE | Troy Fumagalli 6 - TE | |
| Kyle Juszczyk 1 - FB | Jack Colletto 2 - FB | |||||
| Jake Moody 1 - K |
| Rush Attempts | Rush Yards | Rush Touchdowns | Yards Per Rush | Pass Attempts | Completions | Pass Yards | Pass Touchdowns | Net Yards Per Passing Attempt | Rush Percentage | Pass Percentage |
|---|---|---|---|---|---|---|---|---|---|---|
| 389 | 1321 | 11 | 3.4 | 593 | 389 | 3789 | 20 | 5.9 | 0.396 | 0.604 |